The Crossroads Guitar Festival is a music festival and benefit concert first held in 2004 and again in 2007 and 2010. The festivals benefit the Crossroads Centre founded by Eric Clapton, a drug treatment center located in Antigua. The concerts are also intended to be a showcase for a variety of guitarists. All were hand-picked by Eric Clapton himself, who addressed the 2007 audience, saying that each were some of the very best, and those who had earned his respect. The 2010 Crossroads festival was held at Toyota Park in Chicago on June 26, 2010, and also features Bill Murray, who once again presented the festival's nonmusical highlights.

DVD track-listing:
Disc 1

"Promise Land"
"Z Rider"
"Traveling Shoes"
"Going Down"
"Killing Floor"
"Six Stings Down"
"Waiting For the Bus"
"Jesus Just Left Chicago"
"Gypsy Blood"
"In My Time Of Dying"
"Bright Lights"
"Long Road Home"
"Our Love Is Fading"
"Blackwaterside"
"Mississippi Blues"
"Roll ‘N’ Tumble"
"One More Last Chance"
"Mystery Train"
"Lay Down Sally"
"Angelina"
"Vonetta"
"Who Did You Think I Was"
"Ain’t No Sunshine"

Disc 2

"Midnight In Harlem"
"Comin’ Home"
"Soulshine"
"Don’t Keep Me Wondering"
"Space Captain"
"Five Long Years"
"Miss You"
"Hammerhead"
"Nessun Dorma"
"Crossroads"
"Hands of the Saints"
"I Shot The Sheriff"
"Shake Your Money Maker"
"Had To Cry"
"Voodoo Chile"
"Dear Mr. Fantasy"
"The Thrill Is Gone"