In the wake of a "dirty bomb" attack, a New York City neighborhood known as "Slime City" has been evacuated, except for the homeless. Four squatters searching for food in the ruins of the Zachary Devon Soup Kitchen discover a supply of Zachary Devon's Home Brewed Elixir and Himalayan Yogurt. When they drink the elixir and eat the yogurt, they are transformed into hideous slime creatures driven to murder - an intermediate step as they are possessed by the spirits of Zachary Devon and the members of his Coven of Flesh, who committed suicide years earlier. When a greedy developer sets his sites on Slime City, he hires a team of mercenaries to wipe out the homeless population. It's a battle royal between the Slime Heads, the mercenaries, and bloodthirsty mutant cannibals