Uma crescente infecção de zumbis toma conta de um isolado campus universitário. Com a esperança de parar a infecção e o fim da praga de zumbis, uma agência secreta do governo é enviada ao local para encontrar o Paciente Zero, o zumbi original que iniciou a infecção, e criar um antídoto. Já no campus, os agentes Alex (Emmanuelle Vaugier) e Ellis (Ed Quinn) percebem que a universidade inteira está contaminada. Em meio a uma gigantesca batalha com os zumbis, Alex e Ellis descobrem que alguns de seus colegas agentes têm seus próprios planos para o DNA zumbi.
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