Mathias, cujo pai diplomata foi morto na Alemanha, decide estudar medicina forense em Paris. No trem, ele tem alguns problemas com a polícia de fronteira, sendo insultado e ameaçado por um homem estranho, que desaparece rapidamente de seu caminho. No dia seguinte, ele descobre em sua bagagem uma cabeça humana. Mathias fica fascinado por ela, sentindo-se responsável (sentinela da memória do proprietário da cabeça) e começa sua própria investigação sobre o 'artefato', o que o leva a lidar com os serviços secretos franceses.
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