William Cole (Bruce Campbell) é um rico industrial que tem parte do cérebro substituído pela massa cinzenta de um motorista de táxi búlgaro (Vladimir Kolev). Ressuscitado pelo cientista maluco Ivan Ivanovich Ivanov (Stacy Keach), Cole não tem nada a ver com seu companheiro de cérebro, a não ser o fato de que ambos foram mortos pela mesma mulher.
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/media/movies/covers/2010/01/3b1a3bcc15b23728de131b23fb12bfe4.jpg "Poster 1 de Filme Man With the Screaming Brain (2005)")
/media/movies/covers/2011/06/12cb6648afcbd07a07f7e0e3829dcf74.jpg "Poster 2 de Filme Man With the Screaming Brain (2005)")
/media/movies/covers/2011/06/077797eec8f2283e55947430b2e9b532.jpg "Poster 3 de Filme Man With the Screaming Brain (2005)")
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