Um laboratório secreto do Governo americano vem tentando criar o Assassino Perfeito usando o DNA dos famosos assassinos Jeffrey Dahmer e John Wayne Gacy. Porém os mesmos escapam e para tentar parar a matança desenfreada que domina as ruas de todo país, é mandado Ringo, um caipira que leva junto a si uma escopeta e uma garrafa de whiskey. Em sua viagem rumo ao Inferno, ele terá que enfrentar seus próprios demônios, além de um exército de Ninjas. Tudo isso leva ao confronto final.
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