Me & My Brother tells about a simple town’s 19 year-old youth Da Hui (Jack) facing a poor childhood and maturing early together with a 20 year old older brother Da En (Thomas) who has an IQ of a 10 year old. They lose both of their parents and depend on their grandmother ever since. He and his childhood friend, Lu Wei Wei (GuiGui) had a relationship that tells of simple love, but fate had them break up and have regrets.