A chegada inesperada de um coração doado a um hospital de Nova York coloca em rota de colisão três profissionais: o experiente cirurgião Boxer (Kelsey Grammer), a jovem médica Jordan (Julia Stiles) e a burocrata Gilroy (Janeane Garofalo). Dinheiro, poder e ideais fazem parte do conflito para decidir entre quem vive e quem morre.
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