Tom (Michael C. Hall) é um cirurgião pediátrico que cuida sozinho de suas filhas, Jenny e Carrie, após sua esposa vir a falecer. No entanto, sua vida muda drasticamente quando uma delas desaparece a caminho de uma festa. Agora, esse pai desesperado inicia uma investigação para descobrir o paradeiro da menina, fazendo com que segredos de pessoas próximas comecem a ser revelados.
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