A série retrata a vida de uma cadelinha mimada, Brandy Harrington, que conhece o coelhinho desastrado Mr. Whiskers no compartimento de carga de um avião com destino ao Rio de Janeiro. Por acidente, Mr. Whiskers ativa uma alavanca e eles são automaticamente ejetados do avião e caem na Floresta Amazônica. Brandy se vê perdida na companhia de Mr. Whiskers e os dois são obrigados a conviver enquanto tentam sobreviver na selva, onde conhecem todo o tipo de animais e vivem diversas aventuras baseadas nas paranóias de Brandy e nas patetices do Mr. Whiskers.
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/media/movies/covers/2011/05/fb21fce852a826b51c7cfef6403cf7e6.jpg "Poster 2 de Série As Aventuras de Brandy & Sr. Bigodes (2004)")
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