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Formada em Artes Dramáticas pela Ernst Busch, em Berlim, Deborah é filha da atriz Angela Brunner e do escritor Walter Kaufmann.
Atua no teatro, na TV e no cinema desde os anos 90, apesar de ter feito pequenas aparições em filmes antes de disso.
Sua atuação tornou-se internacionalmente conhecida na série "Dark", da Netflix, onde interpretou Regina Tiedemann.
Pais: Angela Brunner, Walter Kaufmann
Irmãos: Rebekka Kaufmann
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