Andrea Fanti (Luca Argentero) perde a memória dos últimos 12 anos de vida devido a um traumatismo cranioencefálico e, pela primeira vez, ele se descobre não mais o médico brilhante e autoritário de antes, mas um simples paciente.
Com uma vida amputada de memórias, o homem cai em um mundo desconhecido onde entes queridos de repente se tornam estranhos e o hospital é o único lugar onde ele realmente se sente em casa.
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