Cha Yo-Han é um médico anestesista. Ele é arrogante, mas é um gênio em sua area de trabalho. Kang Shi-Young é uma residente de anestesiologia que trabalha com Cha Yo-Han. Ela é inteligente, calorosa e ouve atentamente seus pacientes. Pessoas com dores agudas ou crônicas misteriosas, chegam ao hospital. Lá, Cha Yo-Han e Kang Shi-Young tentam encontrar as causas de suas dores.
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