Metamorphosis is a documentary that follows several westerners as they undergo five Ayahuasca ceremonies and experience the gamut of emotions - from utter fear to outright ecstasy. It also explores the shamans who work with the medicine as well as all the key elements of an Ayahuasca ceremony. The film also tells the story of Hamilton Souther, who earlier in life had no belief of and in spirit. After having a spiritual awakening, Hamilton is led to the Amazon where he apprentices as an Ayahuascero, or person who practices medicine with Ayahuasca. Hamilton and Maestro Don Alberto (an indigenous master shaman for over thirty years that practices with Hamilton) take us through the ceremonies as well as explain the meaning behind them.