As amigas Max (Isabelle Fuhrman) e Ellie (Liana Liberato) decidem deixar suas cidades do interior e partir numa viagem cheia de aventura, atravessando o país para conhecer a ex-primeira-dama Eleanor Roosevelt. Elas saem escondidas no conversível azul do pai de Ellie (Luke Wilson) e partem com o cabelo ao vento e o rádio bem alto. Tentando escapar do pai de Ellie e da polícia, as meninas encontram uma mistura excêntrica de pessoas, que fazem essa experiência ser divertida e única.
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