Lupe was one of the last films that Warhol made with Edie, although she did appear in reels 38 (Edith Sedgwick) and 41 (Edith and Ondine) of ****(aka Four Stars or The Twenty Five Hour Movie). The Edie footage in **** was "probably filmed around the end of 1966." (FAW25). She was also reputedly in The Andy Warhol Story (or Rene as Andy), which is described by the Andy Warhol Film Project (Whitney Museum of American Art) as "an unreleased and reportedly vicious two-reel feature made in 1966, in which both Rene Ricard and Edie pretend to be Andy Warhol.

Lupe was based on the story of of Lupe Velez who planned to commit the most beautiful suicide but ended up dying with her head in the toilet vomiting.