After working for the Count Von Salchichen of Frankfurt for over five hundred years, Don Manuel Malasangre decides to take his peculiar family of vampires back to Spain.
But nothing works out as planned and by accident the family gets splited up, still far away from their destination.
Thus, Don Manuel ends up in New York helping an alien to save the Statue of Liberty from a property speculator supported by the shadowy Union of American Vampires.
At the end, Don Manuel becomes a hero of this crazy adventure.
An expressionistic visual style and ironic dialogues are used to appeal to all the family.