U R My Jaan is a love story about Reena (Preeti) and Akash (Mikaal) who're opposites. Reena is a vivacious middle-class girl who have dream to be an actor from Chandigarh, who nurtures the dream of making it big in Bollywood. Akash, from New York, is a renowned, suave & ruthless billionaire, who will go to any lengths when it's his business. They are brought together by fate in Mumbai, and in their brief encounter, they manage to change each other's lives forever.