Em A Última Missão, uma coleta de dinheiro de rotina toma um rumo radical quando dois motoristas de caminhão blindado, RUSSELL (Eddie Murphy) e TRAVIS (Pete Davidson), são emboscados por criminosos implacáveis liderados por uma mente brilhante, ZOE (Keke Palmer), com planos que vão muito além da carga de dinheiro. À medida que o caos se instala ao redor deles, a dupla improvável precisa lidar com perigos de alto risco, personalidades conflitantes e um dia muito ruim que só piora.
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