Um traficante da máfia lança nas ruas um novo estimulante altamente viciante chamado HT25, derivado de tubarões mantidos em cativeiro em um laboratório secreto e que causa efeitos colaterais monstruosos. Após uma explosão e vazamento no laboratório, um exército de tubarões mutantes e sedentos de sangue e outras criaturas são soltos no mundo enquanto um pequeno grupo de pessoas tenta impedir a carnificina.
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