O elenco do programa reúne os humoristas Marcelo Adnet, Dani Calabresa, Bento Ribeiro, Fabio Rabin, Rafael Queiroga e Guilherme Santana, além da equipe do Deznescessários (Paulinho Serra, Tatá Werneck e Rodrigo Capella); jovens atores que fazem parte da cena stand-up comedy do Brasil. O programa é dirigido por Rafael Queiroga e Gabriel Barros e vai ao ar na terça-feira, às 22h30, sendo reprisado na quarta (00h30), quinta (16h30),sábado (22h15) e aos domingos[18h00].[2] Ao contrário do seu antecessor, Furfles MTV, o Comédia não possui temas.
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