Em Reno, Nevada, Deloris Van Cartier (Whoopi Goldberg) é uma cantora que acidentalmente testemunha um brutal assassinato cometido pelo seu namorado, Vince LaRocca (Harvey Keitel), um gângster. Enquanto tentam capturar Vince, um detetive, Eddie Souther (Bill Nunn), é encarregado de protegê-la. Deloris é colocada no programa de proteção às testemunhas e é mandada para um convento em São Francisco disfarçada de freira, usando o nome de irmã Mary Clarence.Mas seu jeito extrovertido, que não é aprovado pela Madre Superiora (Maggie Smith), acaba fazendo ela dar uma nova vida ao coral, chamando a atenção das pessoas e de Vince.
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