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Guided Mouse-ille (or Science on a Wet Afternoon) is a 1967 Tom and Jerry cartoon, produced by Chuck Jones and directed by Abe Levitow. It was the second of three space-age Tom and Jerry shorts to be released in the Chuck Jones era (along with O-Solar Meow and Advance and Be Mechanized), though taking a look at the MPAA code at the beginning of the cartoon would suggest that Guided Mouse-ille (or Science on a Wet Afternoon) was the first of the three cartoons to be produced. According to episode number, It is the last Tom and Jerry cartoon to feature music by Eugene Poddany (both regarding ones produced by Chuck Jones/Sib Tower 12, and also regarding Tom and Jerry cartoons altogether). However, O-Solar Meow could be the last specific cartoon according to the MPAA code to be produced. The cartoon was animated by Don Towsley, Tom Ray, Dick Thompson, Ben Washam, Ken Harris and Philip Roman, with music by Eugene Poddany and backgrounds by Thelma Witmer.

The title is a pun on "Guided missile" and Séance on a Wet Afternoon. Chuck Jones had previously used a "guided missile" pun for Guided Muscle, a Warner Bros. cartoon in the Looney Tunes series featuring Wile E. Coyote and Road Runner.