A capitã Sara Bellaiche, da Polícia de Toulouse, investiga uma transação de tráfico de drogas ligada ao assassinato de dois adolescentes, investigação liderada por Richard Cross da Criminal de Paris. Forçados a colaborar para encontrar o assassino e impedir a corrida sangrenta, Sara e Richard, apesar de seus métodos opostos, são lançados numa corrida frenética nas estradas da Espanha e da França.
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