While in the early stages of his comic book career, Remender worked in animation on such films as The Iron Giant, Anastasia, Titan A.E. and The Adventures of Rocky and Bullwinkle.

In 1998 he teamed up with Harper Jaten and Rory Hensly to create the absurdist humor comic Captain Dingleberry'. After four issues self-publishing the series was picked up by SLG Publishing.

His next series, Black Heart Billy, was also at SLG with collaborator Kieron Dwyer.

In 1999, while producing Black Heart Billy, Remender produced the horror comic Doll and Creature with John Heebink and Mike Manley.

From 2000-2003 Remender went on to do co-create and direct an animated series Swing Town for Wild Brian Animation. He also produced comics and album covers for Fat Wreck Chords, a Bay Area punk label. During this time he taught comics, animation, and storyboards at the Academy of Art University, Inked The Avengers, and penciled numerous issues of the Teenage Mutant Ninja Turtles.

From 2004 to 2005 Remender launched Fear Agent, Sea of Red and Strange Girl with Image Comics, Night Mary at IDW, and he illustrated the comic book adaptation of the movie Man With the Screaming Brain, by Dark Horse Comics. A year later he drew the series The Last Christmas, which was written by Brian Posehn and Gerry Dugan.

During this time he would team up with French artist Paul Renaud for a Red Sonja one-shot published by Dynamite Entertainment titled "Vacant Shell".[2] He is also working on the horror line Crawl Space with Kieron Dwyer, which will include stories like XXXombies.[3] He had previously worked with Dwyer on Sea of Red[4] and Night Mary.[5]

Remender was working on the Dark Horse Comics series The End League,[6] as well as launching a giant robot series Gigantic,.[7][8] He also relaunched Fear Agent[9] and started, for Image Comics, a new horror miniseries called Sorrow.[10]

He became co-author of Punisher War Journal with Matt Fraction from issue #19 to 25 and then was the main writer on the new and eighth Punisher series. IDW Publishing also released a "master edition" of Black Heart Billy.[11] In April 2009, Remender signed an exclusive writing contract with Marvel Comics[12] but was still able to release the series The Last Days of American Crime through Radical Comics.[13][14] In late 2010 he launched the new title Uncanny X-Force.[15][16]

He served as a writer on Electronic Art's game Dead Space and was the lead writer for Epic Games' Bulletstorm, which was released on February 22, 2011.

He has also done work for some punk CDs, including the SideOneDummy Records 1999 compilation Start Your Engines, NO USE FOR A NAME's 2001 "Live in a Dive album", Lagwagon's 2001 "Live in a Dive album", NOFX's 2006 EP Never Trust a Hippy and promo art for 3 Inches of Blood.