A história acompanha a vida de Alex, médica do Hope-Zion Hospital e noiva de Charlie, chefe de cirurgia. Quando Charlie entra em coma, Alex se une ao cirurgião Joel para mantê-lo vivo enquanto buscam encontrar uma forma de trazê-lo de volta. Enquanto isso, o espírito de Charlie vagueia pelo hospital, preso entre os dois mundos, tendo como companhia as almas daqueles que morrem no local, mas que já estão de partida.
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