O ano é 2001. Poucas semanas após o 11 de Setembro, outro ato de terrorismo chocou os Estados Unidos quando cartas anônimas contendo o vírus anthrax foram enviadas para vítimas aleatórias na Flórida, Washington, Capital e Nova York. O ataque ceifou cinco vidas e causou mais pânico ao redor do país, levando cientistas, FBI e departamentos do governo num caminho de falsas pistas e um chocante suspeito principal.
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