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O seriado centra-se na família Walker, uma família americana descendente de irlandeses e judeus. Alguns de seus membros fazem parte do negócio da família Ojai Foods Co., uma distribuidora e produtora de alimentos. A maior parte da ação se passa na grande área de Los Angeles. A casa dos Walker se encontra em Pasadena, Califórnia. O núcleo principal da árvore genealógica da família inclui o falecido patriarca William, a mãe Nora e seus cinco filhos: Sarah, Kitty, Tommy, Kevin e Justin. O irmão de Nora, Saul Holden auxilia nas questões empresariais e familiares.
Emissora: ABC • Episódios: 22 • Duração: 42 min.
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/media/movies/covers/2012/01/c7c49673afacfa818864aba2cc57100a.jpg "Poster 1 de Série Brothers & Sisters (5ª Temporada) (2010)")
/media/movies/covers/2010/10/c985fb09833b55a311b1ebf980dfecd4.jpg "Poster 2 de Série Brothers & Sisters (5ª Temporada) (2010)")
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