Daryl Zero (Bill Pullman) é um investigador particulas. Ele e seu assistente, Steve Arlo (Ben Stiller), costumam resolver crimes impossíveis. Mas, quando não está trabalhando, Zero não faz a mínima idéia do que fazer de sua vida. Sua vida social é nula. Solitário, o investigador costuma escrever péssimas canções e azucrinar seu companheiro. Em seu caso mais recente, Zero deve descobrir quem está chantageando um rico empresário. Só que os problemas aumentam quando ele se envolve emocionalmente.
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