Os agentes especiais Jack e Stephanie escoltam um condenado que vai a tribunal testemunhar contra os seus parceiros. Para despistarem a máfia seguem por uma estrada abandonada conhecida por rota 666. A rota oculta um grande acidente que ocorreu à alguns anos atrás - os corpos de quatro membros de uma quadrilha foram mortos durante um horripilante massacre e a estrada ainda reflete este legado brutal. Os agentes e a testemunha são perseguidos por mortos-vivos vingativos que aparecem ao longo de todo o seu percurso.
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