Acusados de invadir uma agência de correios, os malandros Billy (Skeet Ulrich) e Buford (Gary Oldman) são presos. Sentenciados a 10 anos de cadeia, eles conseguem escapar da "van" que os transportam para a prisão. Separam-se então pela primeira vez em suas vidas. Billy pega uma carona e testemunha um acidente no qual o único sobrevivente é um bebê. Com ele no colo, Billy reencontra o amigo e os três, juntos, vivem uma louca aventura ao lado de personagens excêntricos.
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/media/movies/covers/2013/01/a0992d32bc996a0f6d4bd38849cf93d4.jpg "Poster 1 de Filme Dois Picaretas e um Bebê (2001)")
/media/movies/covers/2019/10/818llkEYEmL._RI_.jpg "Poster 2 de Filme Dois Picaretas e um Bebê (2001)")
/media/movies/covers/2011/02/1e25c502402c44f2daa23a6003402ce2.jpg "Poster 3 de Filme Dois Picaretas e um Bebê (2001)")
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