Em Nova York, há 4 anos, uma epidemia disseminada por baratas quase exterminou com as crianças da cidade. Assim os cientistas desenvolveram um microorganismo, "Judas", destinado a simular e derrotar as baratas contaminadas em seu habitat. O plano deu certo, mas o inseto criador evoluiu e começou a simular sua próxima presa: os humanos. Acreditava-se que estivessem mortas, mas as baratas sofreram outra mutação e agora estão gigantescas e mais mortais do que nunca.
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