Uma pandemia global sem precedentes resultou na evolução de uma nova espécie. Uma forma agressiva da raiva transforma o infectado em predador, viciado em violência. Um sobrevivente humano inexplicavelmente dotado com a capacidade de falar a sua língua nova lidera uma caçada ao Paciente Zero, a fim de encontrar uma cura para salvar sua mulher infectada e da humanidade.
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