Nicholas "Oz" Oseransky (Matthew Perry) é um pacato dentista que vive no subúrbio de Montreal, Canadá. Seu novo vizinho é Jimmy Tudeski (Bruce Willis), um assassino fugitivo de uma perigosa família mafiosa de Chicago. Apesar das diferenças, Jimmy e Oz têm algo em comum: alguém quer matá-los. Se para Jimmy enfrentar uma dupla de assassinos contratados é moleza, para Oz isto é algo completamente novo e amedrontador. Para permanecerem vivos, eles terão que agir juntos: Jimmy com seu sangue frio e precisão certeira e Oz com suas ferramentas de dentista.
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