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Christina Applegate é uma atriz norte-americana, conhecida por ter interpretado Kelly Bundy na série da Fox Broadcasting Company, Married... with Children. Ela tem, desde então, estabeleceu uma carreira cinematográfica e televisiva, com os principais papeis em vários filmes, incluindo Viva! A Babá Morreu, Tiro e Queda, Tudo Para Ficar Com Ele, O Âncora: A Lenda de Ron Burgundy, A Farsa dos Pinguins e Alvin e os Esquilos 2. Ela também estrelou em várias produções, incluindo o revival de musical da Broadway, Sweet Charity. Mais recentemente, ela desempenhou a personagem Samantha Newly na série da ABC, Samantha Who?.
Em 3 de agosto de 2008, a revista People informou que Applegate foi diagnosticada com câncer de mama. Isto foi confirmado pelo seu representante, que disse em uma declaração: "Christina Applegate foi diagnosticada com uma forma precoce de câncer de mama. Beneficiada de detecção precoce, o câncer não acarreta risco de vida. Christina está seguindo o recomendado tratamento de seus médicos e terá uma recuperação completa. Nenhuma outra declaração será emitida neste momento".
Em 19 de agosto de 2008, foi anunciado que Applegate estava livre do câncer após uma mastectomia dupla (que consiste em retirar os dois seios), apesar do câncer ter sido encontrado em apenas uma mama. Ela tem um defeito genético herdado, um BRCA1, o que muitas vezes provoca o câncer de mama. Sua mãe, Nancy Priddy, é também uma sobrevivente do câncer de mama.
Applegate, se submeteu a uma cirurgia reconstrutora dos seios durante os oito meses seguintes.
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