Iris Simpkins (Kate Winslet) escreve uma coluna sobre casamento bastante conhecida no Daily Telegraph, de Londres. Ela está apaixonada por Jasper (Rufus Sewell), mas logo descobre que ele está prestes a se casar com outra. Bem longe dali, em Los Angeles, está Amanda Woods (Cameron Diaz), dona de uma próspera agência de publicidade especializada na produção de trailers de filmes. Após descobrir que seu namorado Ethan (Edward Burns) não tem sido fiel, Amanda encontra na internet um site especializado em intercâmbio de casas. Ela e Iris entram em contato e combinam a troca de suas casas, com Iris indo para a luxuosa casa de Amanda e esta indo para a cabana no interior da Inglaterra de Iris. Logo a mudança trará reflexos na vida amorosa de ambas, com Iris conhecendo Miles (Jack Black), um compositor de cinema que trabalha com Ethan, e Amanda se envolvendo com Graham (Jude Law), irmão de Iris.
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