Na trama, as terríveis crises de TPM da enfermeira Monique (Paloma Bernardi) pioram quando ela perde uma promoção no trabalho e se sente intimidada por seu chefe abusivo. Sem nenhum filtro, Monique decide cuidar de si mesma e fazer justiça com as próprias mãos. A Monique de TPM é determinada e sedutora, mas também é impiedosa e possessiva. No início, ser outra mulher na TPM só ajuda Monique, mas essa "nova" mulher pode colocar tudo a perder e ela vai precisar encontrar um equilíbrio entre suas duas versões.
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