O repórter Lee Taylor (Lee Tracy) está investigando uma série de assassinatos patológicas que tiveram lugar ao longo de meses em Nova York. Os assassinatos acontecem a noite de lua cheia,os jornais falam que ele é "o assassino da Lua". Logo apos os assassinatos os órgãos são canibalizados. As testemunhas o descrevem como um "monstro" que está com a cara desfigurada.
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