Estudantes são expostos a um vírus mortal que se espalha através do contato humano durante o Spring Break. Os infectados criam um apetite insaciável por carne humana. Ao voltar para casa, os jovens espalham a infecção para seus colegas e outras pessoas da cidade. Um a um, mais estudantes são vítimas da praga, desencadeando uma epidemia que gera uma horda de zumbis famintos.
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