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Após um arquivo do sistema de proteção à testemunha ser roubado do Governo dos Estados Unidos, uma série de cinco assassinatos de participantes do programa ocorre. Para desvendar o caso é contratada a Agência de Detetives Charles Townsend, que coloca Natalie (Cameron Diaz), Dylan (Drew Barrymore) e Alex (Lucy Liu) na investigação. A principal suspeita de ter cometido o roubo e os assassinatos é Madison Lee (Demi Moore), uma ex-pantera que deixou a agência tempos atrás para entrar no mundo do crime.
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/media/movies/covers/2010/10/619c27d1f0e51580ce251c442c61ccdd.jpg "Poster 1 de Filme As Panteras: Detonando (2003)")
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